Syntheses and bioactivities of novel carbamates combining platelet activating factor (PAF) receptor antagonist with thromboxane synthase inhibitor (TxSI)

Bioorg Med Chem Lett. 2002 May 20;12(10):1383-6. doi: 10.1016/s0960-894x(02)00186-5.

Abstract

Synthesis of carbamates 3b which possess dual-acting PAF antagonist/TxSI using unstable esters 1, diazepines 2, K2CO3 and 18-crown-6 is described.

Publication types

  • Comparative Study

MeSH terms

  • Azepines / pharmacology
  • Carbamates / chemical synthesis*
  • Carbamates / pharmacology
  • Drug Design
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology
  • Kinetics
  • Models, Molecular
  • Molecular Conformation
  • Platelet Membrane Glycoproteins / antagonists & inhibitors*
  • Receptors, Cell Surface*
  • Receptors, G-Protein-Coupled*
  • Stereoisomerism
  • Structure-Activity Relationship
  • Thromboxane-A Synthase / antagonists & inhibitors*

Substances

  • Azepines
  • Carbamates
  • Enzyme Inhibitors
  • Platelet Membrane Glycoproteins
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • platelet activating factor receptor
  • Thromboxane-A Synthase