Abstract
Synthesis of carbamates 3b which possess dual-acting PAF antagonist/TxSI using unstable esters 1, diazepines 2, K2CO3 and 18-crown-6 is described.
MeSH terms
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Azepines / pharmacology
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Carbamates / chemical synthesis*
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Carbamates / pharmacology
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Drug Design
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology
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Kinetics
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Models, Molecular
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Molecular Conformation
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Platelet Membrane Glycoproteins / antagonists & inhibitors*
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Receptors, Cell Surface*
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Receptors, G-Protein-Coupled*
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Stereoisomerism
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Structure-Activity Relationship
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Thromboxane-A Synthase / antagonists & inhibitors*
Substances
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Azepines
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Carbamates
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Enzyme Inhibitors
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Platelet Membrane Glycoproteins
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Receptors, Cell Surface
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Receptors, G-Protein-Coupled
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platelet activating factor receptor
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Thromboxane-A Synthase